X-omics member Martin Giera (LUMC) and Rik van der Kant (VUMC) received a Chan Zuckerberg Initiative (CZI) seeding grant of $150,000 for their Neurolipid Atlas project. With this project, they are the first Dutch researchers to join the Neurodegeneration Challenge Network (NDCN), founded by CZI.
This project aims to analyze the lipidome of human iPSC-derived neurons and glia, gene-edited for specific disease variants, and will generate the first map of disease-specific, genotype-specific and cell type-specific changes in the human lipidome associated with neurodegenerative diseases.
If their project will have a successful evaluation after 18 months, they may qualify for a supplementary grant of $1.6 million for the next 4 years.
Do you know that X-omics has its own YouTube channel?
All kinds of videos and recordings are already shared here:
In the coming years, more of these type of videos will be uploaded.
The aftermovie of the X-omics festival 2020 will be online soon! Go subscribe to our channel, so you will know when it is online.
Save the date!
The third X-omics festival “the future of X-omics research is now!” will take place on Monday April 12th 2021. This event will take place in Nijmegen, the Netherlands or online (depending on the corona measures that apply in April 2021).
Registration for the festival is already open. In the registration you can indicate in what type of set up (in-person or online) you would like to join.
Olaf Riess, professor Medical Genetics at the University of Tübingen, Germany, will be the keynote speaker of this third edition and he will talk about “Diagnostics of Rare Diseases: Beyond the exome”
Have a look at our festival page for more information about the event and our speaker(s).
More details about the program will follow soon.
Make sure to register yourself via the button below:
In October, X-omics will be present at three online conferences, HUPO2020, BioSB2020 and Metabolomics2020.
During these online conferences, X-omics will be presenting its virtual booth in the exhibit halls. Our staff is present to answer any specific questions you have via chats and to videotalk to you!
Not attending any of these events and want to check out our virtual booth? No problem, you can find it here.
On October 28th, Peter-Bram ‘t Hoen (leader of the X-omics data pillar), will present in the parallel topic session “ELIXIR-NL: FAIR resources and training”. He will talk about “Applying the FAIR Data principles to a Rare Disease registry: a case study of the VASCA registry.” Go check out this presentation at 10:15 AM CET.
Also, make sure to check out the poster sessions, a lot of excellent work done by other consortium members will be shown here.
Consortium members Karlien Coene and Purva Kulkarni will be present to show their latest work during the poster sessions:
• 175, “Identification of novel diagnostic biomarkers for classical homocystinuria through untargeted metabolomics/next generation metabolic screening” by Karlien Coene, Radboudumc.
• 228, “Towards precision diagnostics: Untargeted metabolomics for the diagnosis of inborn errors of metabolism in individual patients” by Purva Kulkarni, Radboudumc.
We hope to see you online during these conferences!
A collaboration between X-omics partner Radboudumc, GeneDx and the Wellcome Sanger Institute has discovered 28 genes that can be linked to developmental disorders.
Exome-sequence datasets from the three different institutes were combined into a cohort of 31,058 patients in order to have more statistical power. It became the largest statistical study of these mutations to date.
The approach and results of this work have been published in the scientific journal Nature. See the link below for the full article.
X-omics consortium member Christian Gilissen jointly supervised this great work and several other consortium members were involved.
On September 28th, X-omics organized the second edition of the X-omics festival “the future of X-omics research is now!”.
The event contained a keynote lecture about the 100,000 Genomes Project, lectures from young investigators, lectures with reference to several application areas and technology pitches.
The second X-omics festival was a success and we thank all the speakers, the sponsors and the participants.
An overview of the highlights, key take home messages, presentations and a link to the festival recordings has been compiled and can be found at our festival page.
We hope to see you again during future X-omics events.
We are excited to announce that our X-omics Genomics core UMC Utrecht has been selected as one of the eight global GeoMx Premier Access Sites. Under this agreement, Edwin Cuppen, Ies Nijman and their team will enable a broader user base to try the Cancer Transcriptome Atlas and evaluate the applicability of GeoMX Digital Spatial Profiler in their research.
NanoString Technologies, a leading provider of life science tools for discovery and translational research, announced the establishment of the GeoMx Premier Access Sites, a global service network that will provide access to the GeoMx Cancer Transcriptome Atlas and future GeoMx commercial assays. The company also announced the availability of the new GeoMx Whole Transcriptome Atlas through the Technology Access Program for the GeoMx Digital Spatial Profiler (DSP). Together these initiatives provide expanded access to next generation sequencing readout on GeoMx DSP.
Cancelation X-omics workshop “Strategies to overcome your challenges in X-omics data integration” (September 29th 2020)
As a result of the current coronavirus measures, the maximum number of participants that could join the workshop in person is limited. Therefore, we have decided to cancel this workshop
An alternative online workshop series will be organized later this year.
We will provide you with further details about this online workshop series in September.
We hope you understand the decision we had to make and that you all will join us during the online workshop series instead.
HUPO Connect 2020 will organize a series of 60 minute webinars as a prelude to the main Congress sessions.
On Thursday 24 September 2020, 16:00 CEST, our leader of the innovation core Proteomics, Albert Heck will participate in the webinar “New Innovations in Proteomics” and talk about “Fishing Within the Proteome with Phosphate and Phosphonate Handles”.
Attendees will be able to submit questions via a text chat or live Q&A directly after the presentations.
Go register yourself for this amazing webinar and receive a discount for the main congress registration.
More information and registration
Our partner Utrecht University and Bruker announce a collaboration to advance the study of the 3-D structures and interactions of proteins by mass spectrometry. The laboratory of Albert Heck at Utrecht University has been a leader in proteomics and the study of protein structure and interactions by mass spectrometry for over two decades. Richard Scheltema recently joined Utrecht University as group leader to focus on crosslinking mass spectrometry (XL-MS) for structural and interaction proteomics.
The collaborative work will focus on the development of TIMS (Trapped Ion Mobility Spectrometry) and PASEF (Parallel Accumulation Serial Fragmentation) methods, along with crosslinkers and XL-MS software for the timsTOF Pro 4D-Proteomics mass spectrometer, in order to take advantage of its unique large-scale, accurate CCS workflows.
Combining the novel, enrichable PhoX crosslinker, developed by Heck and Scheltema, with the extreme speed and sensitivity of PASEF methods on the timsTOF Pro platform, enables the discovery of more crosslinked products which yield more information about protein structures and interactions.